Gut healing, tendon/ligament repair, wound healing
Not FDA-approved
Prohibited (S0)
Oral, SC, IV
Overview
BPC-157 is a 15-amino-acid synthetic peptide derived from a protective protein naturally found in human gastric juice [1]. Originally discovered in the early 1990s as part of a cytoprotection research program, this peptide does not occur naturally in its current isolated form but has been chemically synthesized for extensive research and development [2].
Research, primarily conducted in animal models, suggests that BPC-157 possesses significant cytoprotective and reparative properties [2].
Research Areas and Claims
While human studies are still in the early stages, widespread preclinical research highlights BPC-157’s potential in the following areas:
-
Gut Health & Ulcers: Accelerates the healing of the gut lining and provides cytoprotection for the gastrointestinal tract [2].
-
Joint & Muscle Recovery: Speeds up the repair of tendons, ligaments, and muscle tissue [2].
-
Wound Healing: Promotes rapid recovery and tissue regeneration at wound sites [3].
-
Neuroprotection: Early evidence suggests potential neuroprotective effects and nervous system support [2].
Mechanism of Action
Note: The exact mechanism of action of BPC-157 is not fully understood. However, based on preclinical models, its reparative properties are believed to be primarily driven by two biological pathways:
- Pro-Angiogenic Signaling: BPC-157 promotes the formation of new blood vessels (angiogenesis). It is associated with VEGFR2 internalization and the activation of the VEGFR2–Akt–eNOS signaling pathway, which is crucial for tissue repair [3].
- Vascular Tone & NO Signaling: It demonstrates Nitric Oxide (NO)-dependent effects, modulating vasomotor tone via the Src–Caveolin-1–eNOS pathway [4].
Clinical Trials
While heavily researched in animal models, large-scale, published human trials are currently limited. The available public records include:
PCO-02 (2015)
PL 14736 (2003)
PL 14736 (2005)
Pilot Study (2025)
| Study & Year | Design | Route | Duration | Key Finding | Ref |
|---|---|---|---|---|---|
| PCO-02 (2015) | Phase I, Healthy | Oral | 2 weeks | No results publicly posted | [5] |
| PL 14736 (2003) | Phase I, Safety/PK | Rectal (Suppository) | — | Abstract only; "first study in man" | [6] |
| PL 14736 (2005) | Phase II, Colitis | Rectal (Enema) | — | Abstract only; double-blind | [7] |
| Pilot Study (2025) | Pilot, Healthy (N=2) | IV Infusion | Single dose | Tolerated up to 20mg | [9] |
Administration Methods in Clinical Trials
Important Safety & Regulatory Information
- FDA Status: Not FDA-Approved. BPC-157 is widely considered a "research peptide." Mainstream reporting notes that unapproved peptides can carry risks regarding purity, contamination, and unknown long-term side effects [10].
- Sports Compliance: Prohibited. BPC-157 is strictly prohibited by the World Anti-Doping Agency (WADA) under the S0 (Non-approved substances) category [10].
- What We Don't Know: It is currently unknown if the robust results seen in animal models directly translate to humans. The optimal dosing, ideal route of administration, and long-term safety profile in humans have yet to be established.
Market Overview
Please note: The following data is based on February–March 2026 pricing. All products are strictly sold as research chemicals. Prices fluctuate based on volume, batch, purity, and presentation.
Injectable
SCLyophilized powder reconstituted for subcutaneous research use.
- Price Range: $2.13 – $13.65 per mg
- Typical Sizes: 5mg, 10mg, 15mg, 20mg, 100mg bulk
- Vendors with pricing: 26
Oral
Capsules & SublingualCapsules (400–500 mcg each) or sublingual tablets.
- Price Range: $2.87 – $10.97 per mg
- Typical Sizes: 24–50mg per bottle
- Vendors with pricing: 5
Nasal Spray
IntranasalPre-mixed intranasal spray. Bioavailability in this route is not established in clinical literature.
- Price Range: $3.97 – $11.76 per mg
- Typical Sizes: 5–30mg per bottle
- Vendors with pricing: 3
Vendor Directory
Data collected February–March 2026. Tables are split by route of administration; vendors without public pricing are listed separately below.
Injectable: Lyophilized Powder (SC)
Bulk Peptide Wholesale
Uther
Planet Peptide
Peptidology
PeptiLab Research
Peptide Partners
Peptide Technologies
Atomik Labz
Verified Peptides
Precision Peptide Co
Nuscience Peptides
PurePEPS
Simple Peptide
Eternal Peptides
Alpha Omega Peptide
Alpha-Gen
Amino Asylum
BioLongevity Labs
Nova Peptide Supply
Paramount Peptides
Swiss Chems
Biotech Peptides
Peptide Sciences
Core Peptides
Pure Bio Labs
Pure Rawz
| Vendor | Sizes (mg) | Price Range ($/mg) | Website |
|---|---|---|---|
| Bulk Peptide Wholesale | 100 (10×10mg) | $2.75 | bulkpeptidesupply.com |
| Uther | 10 / 20 / 40 | $2.13 – $4.50 | utherpeptide.com |
| Planet Peptide | 10 | $3.70 – $8.90 † | planetpeptide.com |
| Peptidology | 10 / 20 / 24 | $3.71 – $5.00 | peptidology.co |
| PeptiLab Research | 10 | $3.80 | peptilabresearch.com |
| Peptide Partners | 20 / 50 / 100 / 200 | $3.90 – $5.30 | peptide.partners |
| Peptide Technologies | 5 / 10 / 15 | $4.00 – $5.80 | peptidetech.co |
| Atomik Labz | 10 | $4.20 | atomiklabz.com |
| Verified Peptides | 10 | $5.30 | verifiedpeptides.com |
| Precision Peptide Co | 10 | $5.50 | precisionpeptideco.com |
| Nuscience Peptides | 5 / 10 / 20 | $5.45 – $7.00 | nusciencepeptides.com |
| PurePEPS | 5 / 10 | $6.00 – $6.60 | purepeps.com |
| Simple Peptide | 10 | $6.12 – $6.80 | simplepeptide.com |
| Eternal Peptides | 10 | $6.50 | eternalpeptides.com |
| Alpha Omega Peptide | 10 | $6.80 | alphaomegapeptide.com |
| Alpha-Gen | 5 | $7.00 | alphagresearch.com |
| Amino Asylum | 5 | $7.00 | amino-asylum.net |
| BioLongevity Labs | 10 | $7.00 ★ | biolongevitylabs.com |
| Nova Peptide Supply | 5 / 10 | $7.00 – $7.50 | novapeptidesupply.com |
| Paramount Peptides | 10 | $7.50 | paramountpeptides.com |
| Swiss Chems | 5 | $8.00 | swisschems.is |
| Biotech Peptides | 5 / 10 | $9.20 – $10.40 | biotechpeptides.com |
| Peptide Sciences | 5 / 10 / 15 | $9.33 – $11.90 | peptidesciences.com |
| Core Peptides | 5 / 10 | $9.70 – $10.40 | corepeptides.com |
| Pure Bio Labs | 10 | $10.00 | purebiolabs.com |
| Pure Rawz | 5 / 10 | $11.47 – $13.65 | purerawz.co |
Oral: Capsules & Sublingual Tablets
Swiss Chems
Bulk Peptide Wholesale
Peptide Sciences
Eternal Peptides
Pure Rawz
| Vendor | Format | Size (mg) | Price ($/mg) | Website |
|---|---|---|---|---|
| Swiss Chems | Capsules (500 mcg/cap) | 30 | $2.87 | swisschems.is |
| Bulk Peptide Wholesale | Capsules (500 mcg/cap) | 50 | $3.00 | bulkpeptidesupply.com |
| Peptide Sciences | Capsules (500 mcg/cap) | 30 | $5.50 | peptidesciences.com |
| Eternal Peptides | Tablets (500 mcg/tab) | 25 | $6.00 | eternalpeptides.com |
| Pure Rawz | Sublingual tabs (400 mcg/tab) | 24 / 48 | $8.60 – $10.97 | purerawz.co |
Nasal Spray (Intranasal)
Pure Bio Labs
Amino Asylum
Pure Rawz
| Vendor | Format | Size (mg) | Price ($/mg) | Website |
|---|---|---|---|---|
| Pure Bio Labs | Nasal spray (~200 sprays / 30mL) | 30 | $3.97 | purebiolabs.com |
| Amino Asylum | Nasal spray (50 mcg/spray) | 5 | $9.00 | amino-asylum.net |
| Pure Rawz | Nasal spray (100 mcg/spray) | 10 | $11.76 | purerawz.co |
* Data Notes: Data collected February–March 2026. Sale prices used where publicly displayed. ★ BioLongevity Labs price reflects a 30% sitewide sale (regular $10.00/mg). † Planet Peptide uses buyer-tiered pricing ($3.70/mg independent researcher, $8.90/mg MD/Clinical). Science.bio is permanently closed and excluded. Prices subject to change. All products sold strictly for in-vitro research purposes only.
No Public Pricing / B2B / Wholesale / Inactive
These vendors carry or have carried BPC-157 but do not list public retail prices. Contact them directly for availability and quotes.
Limitless Life Nootropics
Suaway Lab Research
Forever Young Pharmacy
Polaris Peptides
Xingruida XDR
LiliPeptide
| Vendor | Status | Website |
|---|---|---|
| Limitless Life Nootropics | Product page 404 (Mar 2026) | limitlesslifenootropics.com |
| Suaway Lab Research | Site down (Feb 2026) | suaway.com |
| Forever Young Pharmacy | Requires consultation | foreveryoungpharmacy.com |
| Polaris Peptides | Requires account login | polarispeptides.com |
| Xingruida XDR | B2B / wholesale only | hkxingruida.com |
| LiliPeptide | B2B / wholesale only | lilipeptide.com |
References
- Sikirić P. "A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC." J Physiol Paris (1993) [PMID: 8298609]
- Sikiric P, et al. "Brain-gut axis and pentadecapeptide BPC 157." Current Neuropharmacology (2016) [PMC5333585]
- Hsieh MJ, et al. "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation." Journal of Molecular Medicine (2017) [PMID: 27847966]
- Hsieh MJ, et al. "Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-eNOS pathway." Scientific Reports (2020) [PMID: 33051481]
- ClinicalTrials.gov. "NCT02637284 | PCO-02 – Safety and Pharmacokinetics Trial." (2015)
- Veljača M, Pavić Sladoljev D, Mildner A, et al. "Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers." Gut 51(Suppl III): A309 (2003)
- Ruenzi M, Stolte M, Veljaca M, Orešković K, Peterson J; Ulcerative Colitis Study Group. "A multicenter, randomized, double-blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis." Gastroenterology 128: 584 (2005)
- Sikiric P, et al. "BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions..." Pharmaceuticals (2025) [PMC12567428]
- Lee E, Burgess K. "Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study." Alternative Therapies In Health And Medicine (2025) [PMID: 40131143]
- Associated Press. "A closer look at the unapproved peptide injections promoted by influencers and celebrities." (Nov 14, 2025)